製品の概要

  • 製品名JNJ 1661010
  • 製品の詳細
    Potent, selective and reversible fatty acid amide hydrolase inhibitor
  • 生理活性の詳細Potent, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 12 nM). Displays >100-fold selectivity for FAAH-1 over FAAH-2. Active in vivo and brain permeable. Displays analgesic effects.
  • 精製度> 99%

製品の特性

  • 体系名N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
  • 分子量365.45
  • 構造式Chemical Structure
  • 分子式C19H19N5OS
  • CAS 番号681136-29-8
  • PubChem 登録番号2809273
  • 保存方法Store at +4°C. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記O=C(Nc1ccccc1)N2CCN(CC2)c3nc(ns3)c4ccccc4
  • 由来

    Synthetic

  • 研究分野

    JNJ 1661010 (ab120999) 使用論文

    This product has been referenced in:
    • Karbarz MJ  et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg 108:316-29 (2009). Read more (PubMed: 19095868) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"