製品の概要

  • 製品名
    JNJ 10191584 maleate (VUF 6002)
  • 製品の詳細
    Selective H4 antagonist
  • 別名
    • VUF 6002
    • VUF6002 maleate
  • 生理活性の詳細

    Highly selective H4 receptor silent antagonist (Ki = 26 nM). Shows >540-fold selectivity over the H3 receptor (Ki = 14.1 µM). Orally active in vivo.

  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Zhang M  et al. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. Pharmacol Ther 113:594-606 (2007). Read more (PubMed: 17275092) »
  • Coruzzi G  et al. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur J Pharmacol 563:240-4 (2007). Read more (PubMed: 17382315) »
  • Terzioglu N  et al. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett 14:5251-6 (2004). Read more (PubMed: 15454206) »

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