This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to JMJD5

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 種交差性

    交差が予測される動物種: Mouse, Rat, Cow, Human
  • 免疫原

    Synthetic peptide corresponding to Human JMJD5 aa 350 to the C-terminus conjugated to keyhole limpet haemocyanin.
    Database link: Q8N371
    (Peptide available as ab36103)

製品の特性

ターゲット情報

  • 機能
    Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
  • 組織特異性
    Weakly expressed in most cells. Highly expressed in breast cancer cells.
  • 配列類似性
    Contains 1 JmjC domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ13798 antibody
    • JmjC domain-containing protein 5 antibody
    • JMJD5 antibody
    • JMJD5 protein antibody
    • jumonji domain containing 5 antibody
    • Jumonji domain-containing protein 5 antibody
    • KDM8_HUMAN antibody
    • Lysine (K) specific demethylase 8 antibody
    • Lysine-specific demethylase 8 antibody
    see all

参考文献

This product has been referenced in:
  • Piao X  et al. Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-?B-Dependent Autophagy. Oxid Med Cell Longev 2017:7085709 (2017). IHC . Read more (PubMed: 28713490) »
  • Youn MY  et al. JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation. J Biol Chem 287:12994-3004 (2012). WB ; Human . Read more (PubMed: 22375008) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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