The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 22285480
追加情報Is unsuitable for WB.
機能Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
組織特異性Isoform Short is found in skeletal muscle and heart.
関連疾患Anhidrosis, isolated, with normal sweat glands
配列類似性Belongs to the InsP3 receptor family. Contains 5 MIR domains.
ドメインThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
翻訳後修飾Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Shows immunolocalization of IP3R-II in rat brain using ab5805.
Anti-ITPR2 antibody (ab5805) 使用論文
This product has been referenced in:
Okamoto Y et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol52:988-97 (2012).
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