製品の概要

  • 製品名Anti-ITPK1 antibody
    ITPK1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ITPK1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (MEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEY I) of Human ITPK1 (NP_055031).

  • ポジティブ・コントロール
    • Human fetal heart lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab82739 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 40 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
  • 組織特異性Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.
  • 配列類似性Belongs to the ITPK1 family.
    Contains 1 ATP-grasp domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3 antibody
    • 4)P(3) 5/6-kinase antibody
    • 4-trisphosphate 5/6-kinase antibody
    • Inositol 1 3 4 triphosphate 5/6 kinase antibody
    • Inositol 1 3 4 trisphosphate 5/6 kinase antibody
    • Inositol 1 antibody
    • Inositol tetrakisphosphate 1 kinase antibody
    • Inositol triphosphate 5/6 kinase antibody
    • Inositol-tetrakisphosphate 1-kinase antibody
    • Inositol-triphosphate 5/6-kinase antibody
    • Ins(1 3 4)P(3) 5/6 kinase antibody
    • Ins(1 antibody
    • ITPK 1 antibody
    • itpk1 antibody
    • ITPK1_HUMAN antibody
    • ITRPK 1 antibody
    • ITRPK1 antibody
    see all

Anti-ITPK1 antibody 画像

Anti-ITPK1 antibody (ab82739) 使用論文

ab82739 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"