製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ISCU
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 14-63 (SALLLRSPRL PARELSAPAR LYHKKVVDHY ENPRNVGSLD KTSKNVGTGL), of Rat ISCU (NP_001099406)

  • ポジティブ・コントロール
    • Rat lung lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron.
  • 組織特異性
    Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.
  • 関連疾患
    Defects in ISCU are the cause of myopathy with exercise intolerance Swedish type (MEIS) [MIM:255125]; also known as myopathy with deficiency of succinate dehydrogenase and aconitase or myoglobinuria due to abnormal glycolysis or hereditary myopathy with lactic acidosis (HML). This autosomal recessive metabolic disease is characterized by lifelong severe exercise intolerance, in which minor exertion causes fatigue of active muscles, shortness of breath, and cardiac palpitations in association with lactic acidosis. The biochemical phenotype is characterized by a deficiency in mitochondrial iron-sulfur proteins and impaired muscle oxidative metabolism.
  • 配列類似性
    Belongs to the nifU family.
  • 細胞内局在
    Cytoplasm. Nucleus and Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2310020H20Rik antibody
    • HML antibody
    • hnifU antibody
    • Iron sulfur cluster assembly enzyme ISCU mitochondrial antibody
    • Iron sulfur cluster scaffold homolog (E. coli) antibody
    • Iron sulfur cluster scaffold homolog antibody
    • Iron-sulfur cluster assembly enzyme ISCU antibody
    • Iscu antibody
    • IscU iron sulfur cluster scaffold homolog antibody
    • ISCU_HUMAN antibody
    • ISU2 antibody
    • MGC74517 antibody
    • mitochondrial antibody
    • NIFU antibody
    • NifU like N terminal domain containing antibody
    • NifU like N terminal domain containing protein antibody
    • NifU like protein antibody
    • NifU-like N-terminal domain-containing protein antibody
    • NifU-like protein antibody
    • NIFUN antibody
    • Nitrogen fixation cluster like antibody
    • OTTHUMP00000238760 antibody
    • OTTHUMP00000238761 antibody
    • OTTHUMP00000238762 antibody
    • OTTHUMP00000238764 antibody
    • OTTHUMP00000238765 antibody
    see all

画像

  • Anti-ISCU antibody (ab113812) at 1 µg/ml + rat lung lysate at 10 µg

    Predicted band size : 18 kDa

プロトコール

参考文献

ab113812 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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