製品の概要

  • 製品名
    Anti-IRS1 (phospho S307) antibody
    IRS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IRS1 (phospho S307)
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Human, African green monkey
  • 免疫原

    Synthetic peptide corresponding to Human IRS1 aa 301-315.
    Sequence: ESITATSpPASMVGGK
    (Peptide available as ab41770)

  • ポジティブ・コントロール
    • 3T3 L1 cells treated with insulin for 10 minutes.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab5599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 µg/ml. Detects a band of approximately 170 kDa (predicted molecular weight: 149 kDa).Can be blocked with Human IRS1 (phospho S307) peptide (ab41770).

ターゲット情報

  • 機能
    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • 関連疾患
    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • 配列類似性
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 翻訳後修飾
    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Garabadu D & Krishnamurthy S Diazepam potentiates the antidiabetic, antistress and anxiolytic activities of metformin in type-2 diabetes mellitus with cooccurring stress in experimental animals. Biomed Res Int 2014:693074 (2014). WB ; Rat . Read more (PubMed: 24995322) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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