製品の概要

  • 製品名Anti-IRS1 antibody, prediluted
    IRS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IRS1, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken
  • 免疫原

    Synthetic peptide:

    SEDLSAYASISFQKQPEDRQ

    , corresponding to amino acids 1223-1242 of Human IRS1

  • ポジティブ・コントロール
    • Human colon carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: Ready-to-use for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
    • 関連疾患Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
    • 配列類似性Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.
    • 翻訳後修飾Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
      Phosphorylation of Tyr-896 is required for GRB2-binding.
    • Information by UniProt
    • 参照データベース
    • 別名
      • HIRS 1 antibody
      • HIRS1 antibody
      • Insulin receptor substrate 1 antibody
      • IRS 1 antibody
      • IRS-1 antibody
      • IRS1 antibody
      • IRS1_HUMAN antibody
      • OTTHUMP00000164234 antibody
      see all

    Anti-IRS1 antibody, prediluted 画像

    • ab53649, used neat, staining Human IRS1 in Colon Carcinoma, using Immunohistochemistry, Formalin Fixed Paraffin Embedded tissue.

    Anti-IRS1 antibody, prediluted (ab53649) 使用論文

    ab53649 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab53649.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"