製品の概要

  • 製品名Anti-IRS1 antibody
    IRS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IRS1
  • 特異性This antibody is specific for IRS1.
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    A synthesized non-phosphopeptide derived from human IRS1 around the phosphorylation site of serine 312 (A-T-SP-O-S)

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab47746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • 関連疾患Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • 配列類似性Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 翻訳後修飾Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

Anti-IRS1 antibody 画像

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab47746 at a 1/50 dilution. Left: untreated sample. Right: sample preincubated with immunizing peptide.

Anti-IRS1 antibody (ab47746) 使用論文

ab47746 has not yet been referenced specifically in any publications.

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