製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab115829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-IRGM antibody (ab69495)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.1% Bovine serum

関連情報

  • 別名
    • IFI1
    • Iigp3
    • Iipg3
    • Immunity related GTPase family M protein 1
    • Immunity related GTPase family, M
    • Immunity-related GTPase family M protein
    • Immunity-related GTPase family M protein 1
    • Interferon inducible protein 1
    • Interferon-inducible protein 1
    • Irgm
    • IRGM_HUMAN
    • IRGM1
    • LPS-stimulated RAW 264.7 macrophage protein 47 homolog
    • LRG 47
    • LRG-47
    • LRG-47-like protein
    • LRG47
    • MGC149263
    • MGC149264
    see all
  • 機能Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
  • 組織特異性Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
  • 関連疾患Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19) [MIM:612278]. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • 配列類似性Belongs to the interferon-inducible GTPase family.
  • 細胞内局在Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
  • Information by UniProt

IRGM peptide (ab115829) 使用論文

ab115829 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115829.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"