Anti-IRGM 抗体 [403CT8.5.5] (ab63230)

製品の概要

• 製品名Anti-IRGM antibody [403CT8.5.5]
  IRGM 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [403CT8.5.5] to IRGM
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Mouse
  
• 免疫原

  Full-length recombinant mouse IRGM protein.

• ポジティブ･コントロール
  • This antibody gave a positive signal in mouse brain and mouse heart tissue lysates.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituent: PBS
• Concentration information loading...
• 精製度Concentrated Culture Supernatant
• ポリ/モノモノクローナル
• クローン名403CT8.5.5
• ミエローマSp2/0
• アイソタイプIgM
• 研究分野
  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

  • Immunology
  • Innate Immunity
  • Cytokines
  • Interferons

  • Stem Cells
  • Hematopoietic Progenitors
  • Intracellular Molecules

  • Cardiovascular
  • Heart
  • Autophagy
  • Other

  • Cancer
  • Signal transduction
  • Autophagy

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Autophagy and mitophagy

  • Cancer
  • Cell Death
  • Autophagy
  • Signal Transduction

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
• 組織特異性Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
• 関連疾患Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19) [MIM:612278]. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
• 配列類似性Belongs to the interferon-inducible GTPase family.
• 細胞内局在Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.

• Target information above from: UniProt accession A1A4Y4 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 15944 Mouse
  • SwissProt: Q60766 Mouse
• 別名
  • IFI1 antibody
  • Iigp3 antibody
  • Iipg3 antibody

  • Immunity related GTPase family M protein 1 antibody
  • Immunity related GTPase family, M antibody
  • Immunity-related GTPase family M protein 1 antibody
  • Immunity-related GTPase family M protein antibody
  • Interferon inducible protein 1 antibody
  • Interferon-inducible protein 1 antibody
  • Irgm antibody
  • IRGM_HUMAN antibody
  • IRGM1 antibody
  • LPS-stimulated RAW 264.7 macrophage protein 47 homolog antibody
  • LRG 47 antibody
  • LRG-47 antibody
  • LRG-47-like protein antibody
  • LRG47 antibody
  • MGC149263 antibody
  • MGC149264 antibody

  see all