製品の概要

  • 製品名Anti-IRF8 antibody
    IRF8 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to IRF8
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide: QRSFFRENQQITV, corresponding to C terminal amino acids 414-426 of Human ICSBP.

  • ポジティブ・コントロール
    • K562 cell lysate
  • 特記事項Principal Names – ICSBP1; IRF8; ICSBP; IRF-8; interferon consensus sequence binding protein 1; H-ICSBP; interferon regulatory factor 8. Official Gene Symbol - ICSBP1. GenBank Accession Number – NP_002154. LocusLink ID - 3394 (human); 15900 (mouse). Gene Ontology terms - RNA polymerase II transcription factor activity; RNA polymerase II transcription factor activity, enhancer binding; immune response; negative regulation of transcription from Pol II promoter.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.30
    Constituents: 0.5% Tris, 0.5% BSA
  • Concentration information loading...
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab3428 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 47 kDa in K562 lysate(predicted molecular weight: 47 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
    • 組織特異性Predominantly in lymphoid tissues.
    • 配列類似性Belongs to the IRF family.
      Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
    • 翻訳後修飾Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • H ICSBP antibody
      • H-ICSBP antibody
      • HGNC:5358 antibody
      • HICSBP antibody
      • ICSBP 1 antibody
      • ICSBP antibody
      • ICSBP1 antibody
      • Interferon consensus sequence binding protein 1 antibody
      • Interferon consensus sequence binding protein antibody
      • Interferon consensus sequence-binding protein antibody
      • Interferon regulatory factor 8 antibody
      • IRF 8 antibody
      • IRF-8 antibody
      • Irf8 antibody
      • IRF8_HUMAN antibody
      • MYLS antibody
      see all

    Anti-IRF8 antibody 画像



    • Predicted band size : 47 kDa


      ab3428 at a 1µg/ml concentration staining ICSBP in K562 lysate (RIPA buffer, 30 µg total protein per lane, 1 hour incubation). Detected by Western blot (ECL).

    Anti-IRF8 antibody (ab3428) 使用論文

    ab3428 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. If you have an...

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