製品の概要

  • 製品名Anti-IRF7 antibody [3D9]
    IRF7 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3D9] to IRF7
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to N terminal amino acids 1-150 of Human IRF7 purified from E.coli.

  • ポジティブ・コントロール
    • Jurkat cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/2000. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
  • 組織特異性Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
  • 配列類似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻訳後修飾In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
    TRAF6-mediated ubiquitination is required for IRF7 activation.
  • 細胞内局在Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IMD39 antibody
    • Interferon regulatory factor 7 antibody
    • Interferon regulatory factor 7H antibody
    • IRF 7 antibody
    • IRF 7A antibody
    • IRF 7H antibody
    • IRF-7 antibody
    • IRF7 antibody
    • IRF7_HUMAN antibody
    • IRF7A antibody
    • IRF7B antibody
    • IRF7C antibody
    • IRF7H antibody
    see all

Anti-IRF7 antibody [3D9] 画像

  • Anti-IRF7 antibody [3D9] (ab70069) at 1/1000 dilution + Jurkat cell lysates at 40 µg

    Secondary
    Goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

Anti-IRF7 antibody [3D9] (ab70069) 使用論文

ab70069 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70069.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"