製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 53 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation.
  • 組織特異性Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
  • 関連疾患Defects in IRF6 are a cause of van der Woude syndrome (VWS) [MIM:119300]; also known as lip-pit syndrome (LPS). It is an autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate. Penetrance is incomplete. Van der Woude and popliteal pterygium syndrome are allelic disorders.
    Defects in IRF6 are the cause of popliteal pterygium syndrome (PPS) [MIM:119500]. PPS is an autosomal dominant developmental disorder characterized by cleft lip and/or cleft palate, and skin and genital anomalies. Penetrance is incomplete and expressivity is variable. It shows orofacial phenotypic similarities with van der Woude syndrome. Van der Woude and popliteal pterygium syndrome are allelic disorders.
    Genetic variation in IRF6 is associated with non-syndromic orofacial cleft type 6 (OFC6) [MIM:608864]; also called non-syndromic cleft lip with or without cleft palate 6. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
  • 配列類似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻訳後修飾Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
  • 細胞内局在Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Interferon regulatory factor 6 antibody
    • IRF 6 antibody
    • IRF-6 antibody
    • IRF6 antibody
    • IRF6_HUMAN antibody
    • LPS antibody
    • OFC 6 antibody
    • OFC6 antibody
    • OTTHUMP00000034677 antibody
    • OTTHUMP00000034678 antibody
    • PIT antibody
    • PPS antibody
    • PPS1 antibody
    • VWS antibody
    • VWS1 antibody
    see all

Anti-IRF6 antibody 画像

  • Human kidney (formalin fixed, paraffin embedded) stained with ab115220 at 2.5 ug/ml followed by biotinylated anti Goat IgG secondary antibody, alkaline phosphatase streptavidin and chromogen.
  • Human prostate (formalin fixed, paraffin embedded) stained with ab115220 at 2.5 ug/ml followed by biotinylated anti Goat IgG secondary antibody, alkaline phosphatase streptavidin and chromogen.
  • Anti-IRF6 antibody (ab115220) at 0.2 µg/ml + Human Ovary lysate in RIPA buffer at 35 µg

    Predicted band size : 53 kDa

Anti-IRF6 antibody (ab115220) 使用論文

ab115220 has not yet been referenced specifically in any publications.

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