製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab10925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報
    ELISA: 1/32000.
    WB: Use at a concentration of 0.2 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 58 kDa) in Human Ovary lysate.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation.
    • 組織特異性
      Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
    • 関連疾患
      Defects in IRF6 are a cause of van der Woude syndrome (VWS) [MIM:119300]; also known as lip-pit syndrome (LPS). It is an autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate. Penetrance is incomplete. Van der Woude and popliteal pterygium syndrome are allelic disorders.
      Defects in IRF6 are the cause of popliteal pterygium syndrome (PPS) [MIM:119500]. PPS is an autosomal dominant developmental disorder characterized by cleft lip and/or cleft palate, and skin and genital anomalies. Penetrance is incomplete and expressivity is variable. It shows orofacial phenotypic similarities with van der Woude syndrome. Van der Woude and popliteal pterygium syndrome are allelic disorders.
      Genetic variation in IRF6 is associated with non-syndromic orofacial cleft type 6 (OFC6) [MIM:608864]; also called non-syndromic cleft lip with or without cleft palate 6. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
    • 配列類似性
      Belongs to the IRF family.
      Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
    • 翻訳後修飾
      Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
    • 細胞内局在
      Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Interferon regulatory factor 6 antibody
      • IRF 6 antibody
      • IRF-6 antibody
      • IRF6 antibody
      • IRF6_HUMAN antibody
      • LPS antibody
      • OFC 6 antibody
      • OFC6 antibody
      • OTTHUMP00000034677 antibody
      • OTTHUMP00000034678 antibody
      • PIT antibody
      • PPS antibody
      • PPS1 antibody
      • VWS antibody
      • VWS1 antibody
      see all

    プロトコール

    Anti-IRF6 antibody (ab10925) 使用論文

    This product has been referenced in:
    • Liu S  et al. NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer. Tumour Biol 37:9671-80 (2016). IHC ; Human . Read more (PubMed: 26801672) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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