製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to IRAKM
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from aa 60~77 of human IRAKM (N Terminal).

  • ポジティブ・コントロール
    • HL-60 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab37809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
ELISA 1/1000.

ターゲット情報

  • 機能
    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
  • 組織特異性
    Expressed predominantly in peripheral blood lymphocytes.
  • 関連疾患
    Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ASRT5 antibody
    • IL 1 receptor associated kinase M antibody
    • IL-1 receptor-associated kinase M antibody
    • IL1 receptor associated kinase M antibody
    • Interleukin 1 receptor associated kinase 3 antibody
    • Interleukin 1 receptor associated kinase M antibody
    • Interleukin-1 receptor-associated kinase 3 antibody
    • IRAK M antibody
    • IRAK-3 antibody
    • IRAK-M antibody
    • Irak3 antibody
    • IRAK3_HUMAN antibody
    see all

画像

  • Anti-IRAKM antibody (ab37809) at 1/100 dilution + HL-60 cell lysate

    Predicted band size : 68 kDa
    Observed band size : 68 kDa
    Additional bands at : 37 kDa. We are unsure as to the identity of these extra bands.

プロトコール

参考文献

ab37809 has not yet been referenced specifically in any publications.

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