製品の概要

  • 製品名Anti-IRAK4 antibody
    IRAK4 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to IRAK4
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human, Recombinant Fragment
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-130 of Human IRAK4, with 26 kDa tag. AAH13316.

  • ポジティブ・コントロール
    • Recombinant protein, K562 cell lysate and human testis tissue sections.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab88124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 35, 51 kDa (predicted molecular weight: 51 kDa).
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 6 µg/ml.

ターゲット情報

  • 機能Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • 関連疾患Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IL-1 receptor-associated kinase 4 antibody
    • Interleukin 1 receptor associated kinase 4 mutant form 1 antibody
    • Interleukin-1 receptor-associated kinase 4 antibody
    • Interleukin1 receptor associated kinase 4 antibody
    • IPD1 antibody
    • IRAK 4 antibody
    • IRAK-4 antibody
    • IRAK4 antibody
    • IRAK4 mutated form 1 antibody
    • IRAK4_HUMAN antibody
    • LOC 51135 antibody
    • NY REN 64 antibody
    • NY REN 64 antigen antibody
    • NY-REN-64 antibody
    • REN64 antibody
    • Renal carcinoma antigen NY-REN-64 antibody
    see all

Anti-IRAK4 antibody 画像

  • Anti-IRAK4 antibody (ab88124) at 5 µg/ml + recombinant protein (immunogen) at 0.2 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 51 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
  • Anti-IRAK4 antibody (ab88124) at 1/500 dilution + K562 cell lysate at 50 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 51 kDa
    Observed band size : 51 kDa
    Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.
  • ab88124 at 6µg/ml staining IRAK4 in human testis tissue.
  • Detection limit for ab88124 is approximately 1ng/ml as a capture antibody.

Anti-IRAK4 antibody (ab88124) 使用論文

ab88124 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"