Anti-IRAK (phospho T100) 抗体 (ab63484)

製品の概要

  • 製品名Anti-IRAK (phospho T100) antibody
    IRAK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IRAK (phospho T100)
  • 特異性This antibody detects IRAK only when phosphorylated at threonine 100.
  • アプリケーション適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human IRAK around the phosphorylation site of threonine 100 (I-I-TP-A-W).

  • ポジティブ・コントロール
    • Human colon carcinoma tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab63484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100.
ELISA 1/20000.

ターゲット情報

  • 機能Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
  • 組織特異性Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.
    Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Il1rak antibody
    • Interleukin 1 receptor associated kinase 1 antibody
    • Interleukin-1 receptor-associated kinase 1 antibody
    • IRAK antibody
    • IRAK-1 antibody
    • Irak1 antibody
    • IRAK1_HUMAN antibody
    • mPLK antibody
    • OTTHUMP00000026014 antibody
    • OTTHUMP00000026015 antibody
    • OTTHUMP00000026020 antibody
    • OTTHUMP00000180621 antibody
    • Pelle antibody
    • Pelle homolog antibody
    • Pelle-like protein kinase antibody
    • Plpk antibody
    see all

Anti-IRAK (phospho T100) antibody 画像

  • This image shows human colon carcinoma tissue stained with ab63484 at 1/50 dilution; with and without the immunising phosphopeptide.

Anti-IRAK (phospho T100) antibody (ab63484) 使用論文

ab63484 has not yet been referenced specifically in any publications.

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Thank you for your enquiry and your interest. My colleague has passed your enquiry to the Scientific Team.

We only found one publication about this phosphorylation site (see below). This site can be phosphorylated in vitro by AKT1. We could n...

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Thank you for your phone call. DISCOUNT CODE: xxxx Expiration date: xxxx I am very pleased to hear you would like to accept our offer and test ab63484 in IHC-Fr. This code will give you 1 free PRIMARY ANTIBODY before the expiration da...

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