製品の概要

  • 製品名Anti-IQGAP1 antibody
    IQGAP1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to IQGAP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Dog, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-KRQSGQTDPLQKEE

    , corresponding to internal sequence amino acids 357-370 of Human IQGAP1 NP_003861.1.

  • ポジティブ・コントロール
    • Human kidney cell lysate, mouse kidney cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 200 kDa (predicted molecular weight: 189 kDa).

ターゲット情報

  • 機能Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
  • 組織特異性Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
  • 配列類似性Contains 1 CH (calponin-homology) domain.
    Contains 4 IQ domains.
    Contains 1 Ras-GAP domain.
    Contains 1 WW domain.
  • ドメインRegions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.
  • 翻訳後修飾Phosphorylation of Ser-1443 by PKC prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HUMORFA01 antibody
    • IQ motif containing GTPase activating protein 1 antibody
    • IQGA1_HUMAN antibody
    • Iqgap1 antibody
    • KIAA0051 antibody
    • p195 antibody
    • Ras GTPase activating like protein 1 antibody
    • Ras GTPase-activating-like protein IQGAP1 antibody
    • RasGAP-like with IQ motifs antibody
    • SAR1 antibody
    see all

Anti-IQGAP1 antibody 画像

  • Anti-IQGAP1 antibody (ab99471) at 1 µg/ml + Human kidney cell lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 189 kDa

Anti-IQGAP1 antibody (ab99471) 使用論文

ab99471 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"