Anti-IP3 receptor (phospho S1598) 抗体 (ab111615)

製品の概要

  • 製品名Anti-IP3 receptor (phospho S1598) antibody
    IP3 receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IP3 receptor (phospho S1598)
  • 特異性ab111615 detects endogenous levels of TPR1 only when phosphorylated at serine 1598(human)/1588(mouse).
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from Human ITPR1 around the phosphorylation site of serine 1598/1588 (R-D-SP-V-L).

  • ポジティブ・コントロール
    • A549 cells; Human cervix carcinoma tissue.
  • 特記事項

    This antibody showed negative results in Western Blot

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

ターゲット情報

  • 機能Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • 組織特異性Widely expressed.
  • 関連疾患Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • 配列類似性Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • ドメインThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻訳後修飾Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • 5-trisphosphate receptor type 1 antibody
    • DKFZp313E1334 antibody
    • DKFZp313N1434 antibody
    • inositol 1 4 5 triphosphate receptor type 1 antibody
    • Inositol 1 4 5 trisphosphate Receptor Type 1 antibody
    • Inositol 1 antibody
    • InsP3R1 antibody
    • IP3 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 1 antibody
    • IP3R 1 antibody
    • IP3R antibody
    • IP3R1 antibody
    • ITPR 1 antibody
    • Itpr1 antibody
    • ITPR1_HUMAN antibody
    • SCA15 antibody
    • SCA16 antibody
    • SCA29 antibody
    • Type 1 inositol 1 4 5 trisphosphate receptor antibody
    • Type 1 inositol 1 antibody
    • Type 1 InsP3 receptor antibody
    see all

Anti-IP3 receptor (phospho S1598) antibody 画像

  • ab111615 at 1/100 dilution staining ITPR1 in A549 cells by Immunofluorescence. The picture on the right is treated with the synthesized phosphopeptide.
  • ab111615 at 1/50 dilution staining ITPR1 in paraffin-embedded Human Cervix tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-IP3 receptor (phospho S1598) antibody (ab111615) 使用論文

ab111615 has not yet been referenced specifically in any publications.

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