製品の概要

  • 製品名
    Anti-IP3 receptor antibody
    IP3 receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to IP3 receptor
  • アプリケーション
    適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthesized peptide derived from an internal region of Human ITPR1.

  • ポジティブ・コントロール
    • COS7 cells; Human cervix carcinoma tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111087 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

ターゲット情報

  • 機能
    Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • 組織特異性
    Widely expressed.
  • 関連疾患
    Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • 配列類似性
    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • ドメイン
    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻訳後修飾
    Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • 細胞内局在
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • 5-trisphosphate receptor type 1 antibody
    • DKFZp313E1334 antibody
    • DKFZp313N1434 antibody
    • inositol 1 4 5 triphosphate receptor type 1 antibody
    • Inositol 1 4 5 trisphosphate Receptor Type 1 antibody
    • Inositol 1 antibody
    • InsP3R1 antibody
    • IP3 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 1 antibody
    • IP3R 1 antibody
    • IP3R antibody
    • IP3R1 antibody
    • ITPR 1 antibody
    • Itpr1 antibody
    • ITPR1_HUMAN antibody
    • SCA15 antibody
    • SCA16 antibody
    • SCA29 antibody
    • Type 1 inositol 1 4 5 trisphosphate receptor antibody
    • Type 1 inositol 1 antibody
    • Type 1 InsP3 receptor antibody
    see all

画像

  • ab111087 at 1/50 dilution staining ITPR1 in paraffin-embedded Human Cervix carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.
  • ab111087 at 1/100 dilution staining ITPR1 in COS7 cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.

参考文献

ab111087 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab111087.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録