製品の概要

  • 製品名
    Ionotropic Agonists Kit
  • 特異性
    A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401), NMDA (ab120052) and D-serine (ab120048).
  • 製品の概要

    A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401) , NMDA ab120052) and D-serine (ab120048). 

    Receptor

    Description 

    AMPA 

    (S)-AMPA:  

    AMPA agonist. 

    Suggested Solvent: Water 

    AMPA 

    (S)-5-Fluorowillardiine hydrochloride:  

    Potent, selective AMPA receptor agonist. Displays higher affinity than AMPA at hGluR1 and hGlurR2, and displays greater selectivity for AMPA receptor subtypes over the kainate receptor hGluR5. 

    Suggested Solvent: Water 

    AMPA 

    Cyclothiazide:  

    Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. 

    Suggested Solvent: DMSO 

    AMPA

    Aniracetam:  

    Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidepressant and anxiolytic in vivo

    Suggested Solvent: DMSO 

    Kainate 

    Kainic acid:  

    Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. 

    Suggested Solvent: Water 

    Kainate 

    (S)-5-Iodowillardiine hydrochloride:  

    Selective GluK1 (formerly GluR5) kainate receptor agonist (EC50 = 83 µM). Partial agonist activity at GluK2 (formerly GluR6/KA2) receptors. Displays low affinity for AMPA and homomeric GluR6 and GluR7 receptors.

    Suggested Solvent: DMSO 

    NMDA 

    NMDA:  

    Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy. 

    Suggested Solvent: Water 

    NMDA 

    D-Serine:  

    Agonist at the NMDA glycine binding site and the inhibitory post-synaptic glycine receptor. 

    Suggested Solvent: Water 

  • 特記事項

    KIT

製品の特性

参考文献

ab120323 has not yet been referenced specifically in any publications.

レビューと Q&A

Thank you for contacting us.

These products are freeze dried to an exact weight so adding 0.5 ml in each product will give you conc. of 10 mM.

0.5 ml addition of water or solvent into each product will give 10 mM solution.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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