Ionotropic Agonists Kit (ab120323)
製品の概要
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製品名
Ionotropic Agonists Kit -
特異性
A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401), NMDA (ab120052) and D-serine (ab120048). -
製品の概要
A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. Products are freeze-dried to an exact weight so that addition of 1 ml or 0.5 ml of solvent provides a stock solution of 5 mM or 10 mM, respectively. The kit contains (S)-AMPA, (ab120005), (S)-5-Fluorowillardiine hydrochloride (ab120399), Cyclothiazide (ab120061), Aniracetam (ab120316), Kainic acid (ab120100), (S)-5-Iodowillardiine hydrochloride (ab120401) , NMDA ab120052) and D-serine (ab120048).
Receptor
Description
AMPA
(S)-AMPA:
AMPA agonist.
Suggested Solvent: Water
AMPA
Cyclothiazide:
Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current.
Suggested Solvent: DMSO
AMPA
Aniracetam:
Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidepressant and anxiolytic in vivo.
Suggested Solvent: DMSO
Kainate
Kainic acid:
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.
Suggested Solvent: Water
Kainate
NMDA:
Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.
Suggested Solvent: Water
NMDA
D-Serine:
Agonist at the NMDA glycine binding site and the inhibitory post-synaptic glycine receptor.
Suggested Solvent: Water
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特記事項
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
KIT
製品の特性
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保存方法
Store at -20°C. Please refer to protocols. -
内容 1 kit ab120005 - (S)-AMPA 1 vial ab120316 - Aniracetam 1 vial ab120061 - Cyclothiazide 1 vial ab120048 - D-Serine 1 vial ab120100 - Kainic acid 1 vial ab120052 - NMDA 1 vial -
研究分野
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機能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. -
組織特異性
Widely expressed in brain. -
配列類似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. -
翻訳後修飾
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. -
細胞内局在
Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2 promotes cell surface expression. - Information by UniProt
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別名
- GLUR 1
- GLUR A
- AMPA 1
see all
関連製品
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Related Products
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab120323 は 1 報の論文で使用されています。
- Zhou X et al. Transplantation of reprogrammed peripheral blood cells differentiates into retinal ganglion cells in the mouse eye with NMDA-induced injury. J Cell Physiol 236:8099-8109 (2021). PubMed: 34101182