生理活性の詳細Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Pignataro G et al. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab27:1-5 (2007).
Read more (PubMed: 16685255) »
García-Villafranca J & Castro J Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol63:1997-2000 (2002).
Read more (PubMed: 12093476) »
Ugarkar BG et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem43:2883-93 (2000).
Read more (PubMed: 10956196) »