Anti-Intersectin 1 抗体 (ab118262)

製品の概要

• 製品名
  Anti-Intersectin 1 antibody
• 製品の詳細
  Rabbit polyclonal to Intersectin 1
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat
• 免疫原

  Recombinant fragment, corresponding to amino acids 646-840 of Human Intersectin 1 (BC116186).

• ポジティブ･コントロール
  • Human fetal brain lysate

製品の特性

• 製品の状態
  Lyophilised:Reconstitute in 200µl Steriled Distilled Water
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  pH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 98% PBS, 1% BSA
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Neuroscience
  • Neurotransmission
  • Secretory Vesicles
  • Regulation

  • Signal Transduction
  • Protein Trafficking
  • Vesicle Transport
  • Regulation

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
• 組織特異性
  Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.
• 配列類似性
  Contains 1 C2 domain.
  Contains 1 DH (DBL-homology) domain.
  Contains 2 EF-hand domains.
  Contains 2 EH domains.
  Contains 1 PH domain.
  Contains 5 SH3 domains.
• ドメイン
  SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.
  The KLERQ domain binds to SNAP-25 and SNAP-23.
• 細胞内局在
  Endomembrane system. Cell junction > synapse > synaptosome. Cell projection > lamellipodium.

• Target information above from: UniProt accession Q15811 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 6453 Human
  • Entrez Gene: 16443 Mouse
  • Entrez Gene: 29491 Rat
  • Omim: 602442 Human
  • SwissProt: Q15811 Human
  • SwissProt: Q9Z0R4 Mouse
  • SwissProt: Q9WVE9 Rat
  • Unigene: 160324 Human

  • Unigene: 40546 Mouse
  • Unigene: 48657 Rat

  see all
• 別名
  • Human intersectin SH3 domain containing protein SH3P17 antibody
  • Intersectin 1 SH3 domain protein antibody
  • intersectin 1 short form variant 3 antibody

  • intersectin 1 short form variant, 11 antibody
  • Intersectin short form antibody
  • intersectin short variant 12 antibody
  • Intersectin-1 antibody
  • Intersectin1 antibody
  • ITSN 1 antibody
  • ITSN antibody
  • itsn1 antibody
  • ITSN1_HUMAN antibody
  • MGC134948 antibody
  • MGC134949 antibody
  • OTTHUMP00000067855 antibody
  • OTTHUMP00000067856 antibody
  • OTTHUMP00000067857 antibody
  • OTTHUMP00000194810 antibody
  • OTTHUMP00000194811 antibody
  • OTTHUMP00000194812 antibody
  • OTTHUMP00000206688 antibody
  • SH3 domain containing protein 1A antibody
  • SH3 domain protein 1A antibody
  • SH3 domain-containing protein 1A antibody
  • SH3D1A antibody
  • SH3P17 antibody
  • Src homology 3 domain containing protein antibody

  see all

プロトコール

• Western blot protocols