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機能
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
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組織特異性
Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.
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配列類似性
Contains 1 C2 domain.
Contains 1 DH (DBL-homology) domain.
Contains 2 EF-hand domains.
Contains 2 EH domains.
Contains 1 PH domain.
Contains 5 SH3 domains.
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ドメイン
SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31.
The KLERQ domain binds to SNAP-25 and SNAP-23.
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細胞内局在
Endomembrane system. Cell junction > synapse > synaptosome. Cell projection > lamellipodium.
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Information by UniProt
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参照データベース
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別名
- Human intersectin SH3 domain containing protein SH3P17 antibody
- Intersectin 1 SH3 domain protein antibody
- intersectin 1 short form variant 3 antibody
- intersectin 1 short form variant, 11 antibody
- Intersectin short form antibody
- intersectin short variant 12 antibody
- Intersectin-1 antibody
- Intersectin1 antibody
- ITSN 1 antibody
- ITSN antibody
- itsn1 antibody
- ITSN1_HUMAN antibody
- MGC134948 antibody
- MGC134949 antibody
- OTTHUMP00000067855 antibody
- OTTHUMP00000067856 antibody
- OTTHUMP00000067857 antibody
- OTTHUMP00000194810 antibody
- OTTHUMP00000194811 antibody
- OTTHUMP00000194812 antibody
- OTTHUMP00000206688 antibody
- SH3 domain containing protein 1A antibody
- SH3 domain protein 1A antibody
- SH3 domain-containing protein 1A antibody
- SH3D1A antibody
- SH3P17 antibody
- Src homology 3 domain containing protein antibody
see all