Anti-Interferon Receptor alpha 抗体 [MM0336-8H46] (ab90498)

製品の概要

  • 製品名Anti-Interferon Receptor alpha antibody [MM0336-8H46]
    Interferon Receptor alpha 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0336-8H46] to Interferon Receptor alpha
  • アプリケーション適用あり: WB, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to the extracellular domain of Human Interferon Receptor alpha.

  • ポジティブ・コントロール
    • U937 human lymphoma cell line.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ポリ/モノモノクローナル
  • クローン名MM0336-8H46
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 関連性Interferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, Interferon Receptor alpha is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R). Interferon Receptor alpha is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of Interferon Receptor alpha complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on Interferon Receptor alpha. IFNAR1 possesses a large N-glycosylated ectodomain.
  • 細胞内局在Membrane; single-pass type I membrane protein.
  • 参照データベース
  • 別名
    • AVP antibody
    • IFN alpha R1 antibody
    • IFN alpha REC antibody
    • IFNAR antibody
    • IFNAR1 antibody
    • IFNBR antibody
    • IFRC antibody
    • interferon (alpha beta and omega) receptor 1 antibody
    • Interferon alpha receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    see all

Anti-Interferon Receptor alpha antibody [MM0336-8H46] (ab90498) 使用論文

ab90498 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The lab tested this antibody in Flow Cytometry on the U937 human lymphoma cell line. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"