製品の概要

  • 製品名Anti-Interferon gamma antibody [XMG1.2] (FITC)
    Interferon gamma 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [XMG1.2] to Interferon gamma (FITC)
  • 標識FITC. Ex: 493nm, Em: 528nm
  • アプリケーション適用あり: ICC/IF, Flow Cyt, ELISAmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Recombinant full length Mouse protein expressed in E. coli

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab87030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18404-Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ELISA Use at an assay dependent concentration. Ab87303 can be used as a capture antibody in a sandwich ELISA for quantifying mouse IFN-? protein levels. Biotinylated form of the antibody can be paired with a suitable purified capture antibody, with purified recombinant human IFN-? as the standard.

ターゲット情報

  • 機能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 組織特異性Released primarily from activated T lymphocytes.
  • 関連疾患In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 配列類似性Belongs to the type II (or gamma) interferon family.
  • 翻訳後修飾Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

Anti-Interferon gamma antibody [XMG1.2] (FITC) (ab87030) 使用論文

This product has been referenced in:
  • Vikingsson A  et al. Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice. Cell Immunol 173:261-8 (1996). Read more (PubMed: 8912885) »
  • Hsieh B  et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). Read more (PubMed: 8598467) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"