製品の概要

  • 製品名Anti-Interferon gamma antibody [XMG1.2]
    Interferon gamma 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [XMG1.2] to Interferon gamma
  • アプリケーション適用あり: Flow Cyt, ELISAmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    E. coli expressed, recombinant mouse IFN gamma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab23637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    Flow Cyt: Membrane permeablisation is required for this application. Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 組織特異性Released primarily from activated T lymphocytes.
    • 関連疾患In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 配列類似性Belongs to the type II (or gamma) interferon family.
    • 翻訳後修飾Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [XMG1.2] (ab23637) 使用論文

    This product has been referenced in:
    • Hsieh B  et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). Read more (PubMed: 8598467) »
    • Cherwinski HM  et al. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166:1229-44 (1987). Read more (PubMed: 2960769) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"