Anti-Interferon gamma 抗体 [DB-1] (ab22543)

製品の概要

  • 製品名
    Anti-Interferon gamma antibody [DB-1]
    Interferon gamma 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [DB-1] to Interferon gamma
  • 特異性
    This antibody reacts with both mouse and rat Interferon gamma. Clone DB-1 exhibits high affinity binding to the natural and recombinant forms and effectively neutralises the anti viral activity of IFN-gamma. It also blocks the induction of La antigen expression on murine keratinocytes.
  • アプリケーション
    適用あり: ELISA, Blocking, Neutralisingmore details
  • 種交差性
    交差種: Mouse, Rat
  • 免疫原

    Recombinant full length rat IFN gamma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab22543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
Blocking
Neutralising
  • 追加情報
    BL: Use at an assay dependent dilution
    ELISA: Use at a concentration of 10 µg/ml, 100ul/well as coating antibody
    Neut: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 組織特異性
      Released primarily from activated T lymphocytes.
    • 関連疾患
      In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 配列類似性
      Belongs to the type II (or gamma) interferon family.
    • 翻訳後修飾
      Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    参考文献

    ab22543 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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