Anti-Interferon gamma 抗体 [B27] (Biotin) (ab24950)

製品の概要

  • 製品名Anti-Interferon gamma antibody [B27] (Biotin)
    Interferon gamma 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [B27] to Interferon gamma (Biotin)
  • 標識Biotin
  • 特異性ab24950 does not bind to denatured Interferon gamma.
  • アプリケーション適用あり: Neutralising, ELISA, Flow Cyt, ICC/IF, IPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein: E. coli expressed recombinant human interferon gamma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab24950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Neutralising
ELISA
Flow Cyt
ICC/IF
IP
  • 追加情報ELISA: Use at an assay dependent dilution.
    Flow Cyt: Use at an assay dependent dilution.
    IF: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Neut: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 組織特異性Released primarily from activated T lymphocytes.
    • 関連疾患In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 配列類似性Belongs to the type II (or gamma) interferon family.
    • 翻訳後修飾Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [B27] (Biotin) (ab24950) 使用論文

    This product has been referenced in:
    • Amara RR  et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292:69-74 (2001). Read more (PubMed: 11393868) »
    • Abrams JS  et al. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 127:5-24 (1992). Read more (PubMed: 1387110) »

    See all 3 Publications for this product

    Product Wall

    Thank you for contacting Abcam regarding ab24950.


    Regarding the expiration of this product, we expect the product to be stable for up to 1 year when stored at 4deg C.


    For storage we do not recommend further diluting the ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"