製品の概要

  • 製品名
    Anti-Interferon gamma antibody
    Interferon gamma 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Interferon gamma
  • 特異性
    The antibody reacts with rat IFN-g of both natural and recombinant origin. The antibody inhibits the biological activity of natural and recombinant rat IFN-g. The antigen specificity was further assessed by ELISA and western blot. No cross-reactivities with other cytokines have been detected.
  • アプリケーション
    適用あり: IHC-Fr, Inhibition Assay, Neutralising, WBmore details
  • 種交差性
    交差種: Rat

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab7740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.
Neutralising Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 組織特異性
    Released primarily from activated T lymphocytes.
  • 関連疾患
    In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 配列類似性
    Belongs to the type II (or gamma) interferon family.
  • 翻訳後修飾
    Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

参考文献

ab7740 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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