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RabMAb

Anti-Integrin beta 7 抗体 [EPR1357] (ab108926)

製品の概要

  • 製品名
    Anti-Integrin beta 7 antibody [EPR1357]
    Integrin beta 7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1357] to Integrin beta 7
  • アプリケーション
    適用あり: WB, ICCmore details
    適用なし: Flow Cyt,IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Integrin beta 7.

  • ポジティブ・コントロール
    • Human peripheral blood mononuclear cell lysate, Human tonsil lystate, and THP-1 cell lysate
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    A trial size is available to purchase for this antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 87 kDa.
ICC 1/100 - 1/250.
  • 追加情報
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • ターゲット情報

    • 機能
      Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
    • 組織特異性
      Expressed in a variety of leukocyte lines.
    • 配列類似性
      Belongs to the integrin beta chain family.
      Contains 1 VWFA domain.
    • ドメイン
      Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
    • 細胞内局在
      Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Gut homing receptor beta subunit antibody
      • Integrin beta 7 subunit antibody
      • Integrin beta-7 antibody
      • Integrin beta-P antibody
      • Integrin, beta 7 antibody
      • ITB7 antibody
      • ITB7_HUMAN antibody
      • Itgb7 antibody
      • Ly69 antibody
      • M290 IEL antigen antibody
      see all

    画像

    • All lanes : Anti-Integrin beta 7 antibody [EPR1357] (ab108926) at 1/1000 dilution

      Lane 1 : Human peripheral blood mononuclear lysate
      Lane 2 : Human tonsil lysate
      Lane 3 : THP-1 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 87 kDa

    参考文献

    ab108926 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab108926.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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