製品の概要

  • 製品名Anti-Integrin beta 4 antibody [439-9B] (Biotin)
    Integrin beta 4 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [439-9B] to Integrin beta 4 (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Cow, Human
  • 免疫原

    CD104 (Integrin beta 4)

  • ポジティブ・コントロール
    • EDTA treated A549 cell line
  • 特記事項


    ab95584 has been reported to have no effect on adhesion of Human colon adenocarcinoma cells

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • 一次抗体 備考ab95584 has been reported to have no effect on adhesion of Human colon adenocarcinoma cells
  • ポリ/モノモノクローナル
  • クローン名439-9B
  • アイソタイプIgG2b
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab95584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 0.25µg for 105-8 cells. ab18542-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
  • 組織特異性Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
  • 関連疾患Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
  • 配列類似性Belongs to the integrin beta chain family.
    Contains 1 Calx-beta domain.
    Contains 4 fibronectin type-III domains.
    Contains 1 PSI domain.
    Contains 1 VWFA domain.
  • ドメインThe fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 104 antibody
    • CD104 antibody
    • CD104 antigen antibody
    • gp150 antibody
    • Integrin beta 4 subunit antibody
    • Integrin beta-4 antibody
    • ITB4_HUMAN antibody
    • ITG B4 antibody
    • ITGB 4 antibody
    • Itgb4 antibody
    see all

Anti-Integrin beta 4 antibody [439-9B] (Biotin) 画像

  • Staining of the A549 cell line with 0.125 µg of Rat IgG2b ? Isotype Control Biotin (open histogram) or 0.125 µg of ab95584 (filled histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-Integrin beta 4 antibody [439-9B] (Biotin) (ab95584) 使用論文

This product has been referenced in:
  • Simon-Assmann P  et al. Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin. J Cell Sci 107 ( Pt 3):577-87 (1994). Read more (PubMed: 8006072) »
  • Falcioni R  et al. Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res 48:816-21 (1988). Read more (PubMed: 2448027) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"