Anti-Integrin beta 4 抗体 [439-9B] (ab110167)

製品の概要

  • 製品名Anti-Integrin beta 4 antibody [439-9B]
    Integrin beta 4 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [439-9B] to Integrin beta 4
  • 特異性Recognizes human Integrin beta-4, a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. Multiple splice variants have been identified.
  • アプリケーション適用あり: WB, IHC-P, IHC-Fr, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Other Immunogen Type corresponding to Human Integrin beta 4.
    Database link: P16144

  • ポジティブ・コントロール
    • Human Pancreas and Human Placenta tissues, A549 cell line

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • バッファーpH: 7.20
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Affinity purified
  • ポリ/モノモノクローナル
  • クローン名439-9B
  • アイソタイプIgG2b
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab110167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 202 kDa.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use 1µg for 105-8 cells. in 100 µl



ab18536-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
  • 組織特異性Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
  • 関連疾患Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
  • 配列類似性Belongs to the integrin beta chain family.
    Contains 1 Calx-beta domain.
    Contains 4 fibronectin type-III domains.
    Contains 1 PSI domain.
    Contains 1 VWFA domain.
  • ドメインThe fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 104 antibody
    • CD104 antibody
    • CD104 antigen antibody
    • gp150 antibody
    • Integrin beta 4 subunit antibody
    • Integrin beta-4 antibody
    • ITB4_HUMAN antibody
    • ITG B4 antibody
    • ITGB 4 antibody
    • Itgb4 antibody
    see all

Anti-Integrin beta 4 antibody [439-9B] 画像

  • ab110167 at 20 µg/ml staining integrin beta 4 in Formalin-Fixed, Paraffin-Embedded Human Pancreas(ab29816). Sections were incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

  • ab110167 at 20 µg/ml staining integrin beta 4 in Formalin-Fixed, Paraffin-Embedded Human Placenta. Sections were incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

  • Staining of the A549 cell line with 0.5 ug of Rat IgG2b Isotype Control (ab98984) (blue histogram) or 0.5 ug of ab110167 (purple histogram) followed by Biotin Anti-Rat IgG and Sav-PE. Total viable cells were used for analysis.

Anti-Integrin beta 4 antibody [439-9B] (ab110167) 使用論文

ab110167 has not yet been referenced specifically in any publications.

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