Anti-Integrin beta 3 抗体 [VIPL2] (Phycoerythrin) (ab91128)

製品の概要

  • 製品名Anti-Integrin beta 3 antibody [VIPL2] (Phycoerythrin)
    Integrin beta 3 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [VIPL2] to Integrin beta 3 (Phycoerythrin)
  • 標識Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特異性ab91128 is specific to the 110 kDa Human Integrin beta 3 and inhibits platelet aggregation and activation induced by thrombin and collagen. ab91128 reacts with platelets, megakaryocytes, megakaryoblasts, endothelial cells, fibroblasts, smooth muscle cells and osteoblasts in complexed form and does not react with the platelets of patients with Glanzmann Thrombasthenia.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Cell suspension containing osteoclasts from osteoclastoma.

  • ポジティブ・コントロール
    • Normal peripheral blood cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab91128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報Flow Cyt: Use 20µl for 106 cells.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    • 組織特異性Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
    • 関連疾患Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
    • 配列類似性Belongs to the integrin beta chain family.
      Contains 1 VWFA domain.
    • 翻訳後修飾Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD 61 antibody
      • CD61 antibody
      • CD61 antigen antibody
      • GP3A antibody
      • GPIIIa antibody
      • GT antibody
      • HPA 1 antibody
      • HPA 4 antibody
      • Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody
      • Integrin beta chain beta 3 antibody
      • Integrin beta-3 antibody
      • ITB3_HUMAN antibody
      • ITG B3 antibody
      • ITGB 3 antibody
      • ITGB3 antibody
      • NAIT antibody
      • Platelet fibrinogen receptor beta subunit antibody
      • Platelet fibrinogen receptor, beta subunit antibody
      • Platelet glycoprotein IIIa antibody
      • Platelet glycoprotein IIIa precursor antibody
      • Platelet membrane glycoprotein IIIa antibody
      • PTP antibody
      see all

    Anti-Integrin beta 3 antibody [VIPL2] (Phycoerythrin) 画像

    • ab91128 at 20µl for /106 cells staining Integrin beta 3 in Human normal peripheral blood cells by Flow Cytometry.
    • ab91128 at 20µl for 106 cells staining Integrin beta 3 in Human normal peripheral blood cells by Flow Cytometry.

    Anti-Integrin beta 3 antibody [VIPL2] (Phycoerythrin) (ab91128) 使用論文

    ab91128 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry.

    I am sorry we do not have the unconjugated version of Integrin beta 3 antibody clone number [C17].

    We do have several other unconjguated mouse monoclonal Integrin beta 3 antibodies tested in WB and IP i...

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