Anti-CD103 抗体 [2E7] (ab25198)
Key features and details
- Armenian hamster monoclonal [2E7] to CD103
- Suitable for: IHC-Fr, IP, Cellular Activation, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG
Related conjugates and formulations
製品の概要
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製品名
Anti-CD103 antibody [2E7]
CD103 一次抗体 製品一覧 -
製品の詳細
Armenian hamster monoclonal [2E7] to CD103 -
由来種
Armenian hamster -
アプリケーション
適用あり: IHC-Fr, IP, Cellular Activation, Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to CD103. C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL)
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特記事項
This antibody is reported to have signal inducing activity in a redirected lysis assay and to co stimulate IEL and CD8+ lymph node cells in conjunction with anti TCR in vitro, which runs counter to the usual inhibition of CTL by anti integrins. The property of costimulation is not unique to the mouse since the combination of anti human alpha IEL (intraepithelial lymphocytes) plus anti TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 8.20
Constituents: 0.95% Sodium borate, 0.6% Boric Acid -
Concentration information loading...
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精製度
Affinity purified -
一次抗体 備考
This antibody is reported to have signal inducing activity in a redirected lysis assay and to co stimulate IEL and CD8+ lymph node cells in conjunction with anti TCR in vitro, which runs counter to the usual inhibition of CTL by anti integrins. The property of costimulation is not unique to the mouse since the combination of anti human alpha IEL (intraepithelial lymphocytes) plus anti TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated. -
ポリ/モノ
モノクローナル -
クローン名
2E7 -
アイソタイプ
IgG -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab25198の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-Fr |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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|
Cellular Activation |
Use at an assay dependent concentration.
|
|
Flow Cyt |
Use at an assay dependent concentration.
ab18479 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
特記事項 |
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IHC-Fr
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Cellular Activation
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab18479 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. -
組織特異性
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16407 Mouse
- SwissProt: Q60677 Mouse
- Unigene: 96 Mouse
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別名
- A530055J10 antibody
- alpha-E1 antibody
- alpha-M290 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab25198 は 1 報の論文で使用されています。
- Zhou J et al. Prognostic and therapeutic value of CD103+ cells in renal cell carcinoma. Exp Ther Med 15:4979-4986 (2018). PubMed: 29805521