Anti-Integrin alpha 5 + beta 1 抗体 [P1D6] (ab75472)


  • 製品名Anti-Integrin alpha 5 + beta 1 antibody [P1D6]
  • 製品の詳細
    Mouse monoclonal [P1D6] to Integrin alpha 5 + beta 1
  • 特異性This antibody reacts with the a5 integrin subunit. It neutralizes binding of alpha5 beta1 to the central cell adhesion domain of fibronectin, which is located within a 80kDa tryptic fragment.
  • アプリケーション適用あり: IP, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human HT1080 fibrosarcoma cells



Our Abpromise guarantee covers the use of ab75472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP 1/1000.
ICC/IF 1/1000.


  • 関連性Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
  • 細胞内局在Integrin alpha 5: Membrane; Single-pass type I membrane protein. Integrin beta 1: Cell membrane; Single-pass type I membrane protein. Melanosome.
  • 参照データベース
  • 別名
    • CD49e antibody
    • FNRA antibody
    • FNRB antibody
    • Integrin alpha 5 antibody
    • Integrin beta 1 antibody
    • ITGA5 antibody
    • ITGB1 antibody
    • MDF2 antibody
    • VLA 5 antibody
    • VLA BETA antibody
    • VLA5 antibody
    see all

Anti-Integrin alpha 5 + beta 1 antibody [P1D6] (ab75472) 使用論文

This product has been referenced in:
  • Wang Q  et al. Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene N/A:N/A (2014). Read more (PubMed: 24632605) »
  • Maherally Z  et al. Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? PLoS One 7:e30691 (2012). ICC/IF ; Human . Read more (PubMed: 22363471) »

See all 3 Publications for this product

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Candida albicans Cell (Hypha and yeast cells)
Permeabilization Yes - Saponin
Specification Hypha and yeast cells
Blocking step BSA as blocking agent for 30 minute(s) · Concentration: 1% · Temperature: 25°C
Fixative Paraformaldehyde

Angela Lopez

Verified customer

投稿 Jul 28 2016

Thank you for your enquiry.

I have been able to confirm thatab75472 Anti-Integrin alpha 5 + beta 1 antibody [P1D6]is sold as ascites. Unpurified antibodies, such as those sold as whole antiserum, ascites or tissue culture supernatant will ...

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That is no problem. If you have any further questions, please do not hesitate to contact us.

Until then, I wish you all the best with your research.

Thank you for contacting us yesterday.

I am sorry that the concentration function on the datasheet of Anti-Integrin alpha 5 + beta 1 antibody [P1D6] (ab75472) does not appear to be functioning properly. We will be looking into this. I can inf...

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Thank you for your inquiry.

Please refer to the following reference:

Wayner EA, Carter WG. Identification of multiple cell surface receptors for fibronectin and collagen in human fibrosarcoma cells possessing unique a and common b s...

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Thank you for your call today and for your questions about ab75472.

I have attached the reference that we discussed, and the protocol for adhesion inhibition can be found on page 3 under the small font "Stage Three: Inhibition of Cell Ad...

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