APC Anti-Integrin alpha 4+beta 7 抗体 [DATK32 (DATK-32)] (ab93539)
Key features and details
- APC Rat monoclonal [DATK32 (DATK-32)] to Integrin alpha 4+beta 7
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG2a
製品の概要
-
製品名
APC Anti-Integrin alpha 4+beta 7 antibody [DATK32 (DATK-32)]
Integrin alpha 4+beta 7 一次抗体 製品一覧 -
製品の詳細
APC Rat monoclonal [DATK32 (DATK-32)] to Integrin alpha 4+beta 7 -
由来種
Rat -
標識
APC. Ex: 645nm, Em: 660nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse Integrin alpha 4+beta 7. TK-1 cell line
-
ポジティブ・コントロール
- Flow Cyt: Mouse spleen cells and C57Bl/6 bone marrow cells.
-
特記事項
Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block Integrin alpha 4 beta 7 mediated cell adhesion.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.12% Monobasic dihydrogen sodium phosphate, 0.88% Sodium chloride, 0.1% Gelatin -
Concentration information loading...
-
精製度
Immunogen affinity purified -
一次抗体 備考
Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block Integrin alpha 4 beta 7 mediated cell adhesion. -
ポリ/モノ
モノクローナル -
クローン名
DATK32 (DATK-32) -
アイソタイプ
IgG2a -
軽鎖の種類
kappa -
研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab93539の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
|
特記事項 |
---|
Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
-
関連性
Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. -
細胞内局在
Membrane; Single pass type I membrane protein. -
参照データベース
- Entrez Gene: 16401 Mouse
- Entrez Gene: 16421 Mouse
- SwissProt: P26011 Mouse
- SwissProt: Q00651 Mouse
-
別名
- Antigen CD49D antibody
- CD49d antibody
- IA4 antibody
see all
画像
データシートおよび資料
-
Datasheet download
参考文献 (3)
ab93539 は 3 報の論文で使用されています。
- Andrew DP et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 153:3847-61 (1994). Flow Cyt . PubMed: 7523506
- Hamann A et al. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152:3282-93 (1994). Flow Cyt . PubMed: 7511642
- Berlin C et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74:185-95 (1993). Flow Cyt . PubMed: 7687523