Anti-Integrin alpha 4+beta 7 抗体 [DATK32] (Biotin) (ab25217)

製品の概要

  • 製品名Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Biotin)
    Integrin alpha 4+beta 7 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [DATK32] to Integrin alpha 4+beta 7 (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: Flow Cyt, IHC-Fr, Blockingmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    AKR/Cum Mouse spontaneous T lymphoma cell line TK1.

  • エピトープab25217 recognizes a conformational epitope on the heterodimer.
  • 特記事項


    ab25217 could be useful for induction of homotypic cellular aggregation.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab25217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 1µg for 106 cells. ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration.

ターゲット情報

  • 関連性Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
  • 細胞内局在Membrane; Single pass type I membrane protein.
  • 参照データベース
  • 別名
    • Antigen CD49D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin beta 7 antibody
    • Integrin beta 7 subunit antibody
    • ITGA4 antibody
    • ITGB7 antibody
    • LPAM1 antibody
    see all

Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Biotin) (ab25217) 使用論文

This product has been referenced in:
  • Andrew DP  et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 153:3847-61 (1994). Read more (PubMed: 7523506) »
  • Hamann A  et al. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152:3282-93 (1994). Read more (PubMed: 7511642) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"