Anti-Integrin alpha 4 抗体 [TA-2] (ab22544)


  • 製品名Anti-Integrin alpha 4 antibody [TA-2]
    Integrin alpha 4 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [TA-2] to Integrin alpha 4
  • 特異性ab22544 recognises rat 150kD alpha 4 chain of VLA-4 (CD49d) on resting and activated T cells, B cells and thymocytes.
  • アプリケーション適用あり: IP, IHC-Fr, Flow Cyt, Inhibition Assaymore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Small peritoneal exudate lymphocytes. (Rat)



Our Abpromise guarantee covers the use of ab22544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
Inhibition Assay
  • 追加情報Flow Cyt: 1/50 - 1/100 (Use 10µl for 106 cells in 100µl)
    IHC-Fr: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Inhib: Use at an assay dependent dilution.
    Note: ab22544 partially inhibits Con A or calcium ionophore/PMA stimulated T cell adhesion to unstimulated, IFN gamma or LPS treated endothelial cels in vitro. We recommend azide free format for this purpose.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
    • 配列類似性Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • ドメインThe SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
    • 翻訳後修飾Phosphorylation on Ser-1027 inhibits PXN binding.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 269C wild type antibody
      • Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody
      • CD49 antigen like family member D antibody
      • CD49 antigen-like family member D antibody
      • CD49d antibody
      • IA4 antibody
      • Integrin alpha 4 antibody
      • Integrin alpha 4 subunit antibody
      • Integrin alpha IV antibody
      • Integrin alpha-4 antibody
      • Integrin alpha-IV antibody
      • Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody
      • ITA4_HUMAN antibody
      • ITGA4 antibody
      • MGC90518 antibody
      • OTTHUMP00000205320 antibody
      • Very late activation protein 4 receptor, alpha 4 subunit antibody
      • VLA 4 subunit alpha antibody
      • VLA-4 subunit alpha antibody
      • VLA4 antibody
      see all

    Anti-Integrin alpha 4 antibody [TA-2] (ab22544) 使用論文

    ab22544 has not yet been referenced specifically in any publications.

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