Anti-Integrin alpha 4 抗体 [PS/2] (Biotin) (ab24944)

製品の概要

  • 製品名
    Anti-Integrin alpha 4 antibody [PS/2] (Biotin)
    Integrin alpha 4 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [PS/2] to Integrin alpha 4 (Biotin)
  • 標識
    Biotin
  • 特異性
    ab24944 recognises Integrin alpha 4.
  • アプリケーション
    適用あり: Functional Studies, Flow Cyt, IP, Inhibition Assaymore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab24944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

Studies of cell-cell interaction and tumor cell metastasis and adhesion; Retardation of myelopoiesis in Dexter-type cultures.

Flow Cyt Use 2µl for 106 cells.

ab18542 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.

Inhibition of lymphopoiesis in Whitlock-Witte long-term bone marrow cultures.

ターゲット情報

  • 機能
    Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
  • 配列類似性
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • ドメイン
    The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
  • 翻訳後修飾
    Phosphorylation on Ser-1027 inhibits PXN binding.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 269C wild type antibody
    • Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody
    • CD49 antigen like family member D antibody
    • CD49 antigen-like family member D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin alpha-4 antibody
    • Integrin alpha-IV antibody
    • Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody
    • ITA4_HUMAN antibody
    • ITGA4 antibody
    • MGC90518 antibody
    • OTTHUMP00000205320 antibody
    • Very late activation protein 4 receptor, alpha 4 subunit antibody
    • VLA 4 subunit alpha antibody
    • VLA-4 subunit alpha antibody
    • VLA4 antibody
    see all

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参考文献

ab24944 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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