Anti-Insulin 抗体 [INS04] (Biotin) (ab79477)


  • 製品名Anti-Insulin antibody [INS04] (Biotin)
    Insulin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [INS04] to Insulin (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Swine Insulin.

  • ポジティブ・コントロール
    • Pancreas.



Our Abpromise guarantee covers the use of ab79477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報IHC-P: 1/25 - 1/50 for 30 min at room temperature.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • 関連疾患Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • 配列類似性Belongs to the insulin family.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IDDM antibody
      • IDDM1 antibody
      • IDDM2 antibody
      • ILPR antibody
      • ins antibody
      • INS_HUMAN antibody
      • Insulin A chain antibody
      • Insulin B chain antibody
      • IRDN antibody
      • MODY10 antibody
      • Preproinsulin antibody
      • Proinsulin antibody
      • Proinsulin precursor antibody
      see all

    Anti-Insulin antibody [INS04] (Biotin) 画像

    • ab79477 staining Insulin in Human pancreas by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Antibody was detected by peroxidase-conjugate and DAB chromogen

    Anti-Insulin antibody [INS04] (Biotin) (ab79477) 使用論文

    ab79477 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry.
    ab79477 has been found to react with human insulin but we have no information available regarding its potential to bind human pro-insulin.
    If you are not looking for an antibody that is biotinilated necessarily, bu...

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    DISCOUNT CODE: xxx for testing ab79477 in ELISA and sELISA
    DISCOUNT CODE: xxx for testing ab65454 in sELISA
    DISCOUNT CODE: xxx for testing ab73797 in ELISA and sELISA

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    Thank you for your phone call.

    The antibody ab65454 was raised against a ˜15 amino acid synthetic peptide in the central region of human insulin. Unfortunately, the epitope for ab79477 has not been mapped, so we are unable to predict whether ...

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    Thank you for your reply. We have not tested this antibody for its cross-reactivity with swine, bovine, or horse.  We have only tested it in human samples.  If we had tested it in other species, and it didn't work, we also would have stated that on...

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    Thank you very much for your interest in ab79477. To our knowledge, ab79477 has not been tested in porcine.  Since the antibody was raised against a poricne sequence, it should work, but since we haven't specifically tested it we can't guarantee it...

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