Anti-Insulin 抗体 [8E2] (ab1967)

製品の概要

  • 製品名Anti-Insulin antibody [8E2]
    Insulin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [8E2] to Insulin
  • 特異性Kass for this antibody is 6.0 x 108M-1. It cross-reacts with human proinsulin. No cross-reaction with free C-peptide.
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Human, Pig
    交差が予測される動物種: Cow
  • 免疫原

    Full length native protein (purified).

  • 特記事項Concentration varies from lot to lot and can be provided on request.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab1967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • 関連疾患Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • 配列類似性Belongs to the insulin family.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IDDM antibody
      • IDDM1 antibody
      • IDDM2 antibody
      • ILPR antibody
      • ins antibody
      • INS_HUMAN antibody
      • Insulin A chain antibody
      • Insulin B chain antibody
      • IRDN antibody
      • MODY10 antibody
      • Preproinsulin antibody
      • Proinsulin antibody
      • Proinsulin precursor antibody
      see all

    Anti-Insulin antibody [8E2] (ab1967) 使用論文

    ab1967 has not yet been referenced specifically in any publications.

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    Thank you for your enquiry.

    I would be pleased to help with your enquiry. In order to do so, could you confirm which antibody you have contacted us about? Is this product code ab1967? Unfortunately, this antibody is no longer available and h...

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    Here is the rest of the information for your customer: Ab1968 - this clone (C7C9) reacts with the c-terminal pentapeptide of the insulin beta-chain. There is unfortunately no epitope information for ab1966 (clone 7F5). If you have any more questions ju...

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    Here is the rest of the information for your customer: Ab1968 - this clone (C7C9) reacts with the c-terminal pentapeptide of the insulin beta-chain. There is unfortunately no epitope information for ab1966 (clone 7F5). If you have any more questions ju...

    Read More

    Thanks for your patience with this one. Here is the epitope information - Ab7760: The epitope specificity was not performed. It reacts with high affinity with the whole insulin molecule (native, under the conditions of RIA) but with much lower affi...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"