製品の概要

  • 製品名Anti-INPP5F antibody
    INPP5F 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to INPP5F
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from N terminal domain of Human INPP5F protein

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 104 kDa.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.
  • 組織特異性Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts.
  • 関連疾患Defects in OCRL are the cause of Lowe oculocerebrorenal syndrome (OCRL) [MIM:309000]. It is an X-linked multisystem disorder affecting eyes, nervous system, and kidney. It is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, aminoaciduria, and reduced ammonia production by the kidney. Ocular abnormalities include cataract, glaucoma, microphthalmos, and decreased visual acuity. Developmental delay, hypotonia, behavior abnormalities, and areflexia are also present. Renal tubular involvement is characterized by impaired reabsorption of bicarbonate, amino acids, and phosphate. Musculoskeletal abnormalities such as joint hypermobility, dislocated hips, and fractures may develop as consequences of renal tubular acidosis and hypophosphatemia. Cataract is the only significant manifestation in carriers and is detected by slit-lamp examination.
    Defects in OCRL are the cause of Dent disease type 2 (DD2) [MIM:300555]. DD2 is a renal disease belonging to the 'Dent disease complex', a group of disorders characterized by proximal renal tubular defect, hypercalciuria, nephrocalcinosis, and renal insufficiency. The spectrum of phenotypic features is remarkably similar in the various disorders, except for differences in the severity of bone deformities and renal impairment. Characteristic abnormalities include low-molecular-weight proteinuria and other features of Fanconi syndrome, such as glycosuria, aminoaciduria, and phosphaturia, but typically do not include proximal renal tubular acidosis. Progressive renal failure is common, as are nephrocalcinosis and kidney stones.
  • 配列類似性Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
    Contains 1 Rho-GAP domain.
  • 細胞内局在Endosome. Also found on macropinosomes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC 3.1.3.36 antibody
    • Inositol polyphosphate 5 phosphatase OCRL 1 antibody
    • Inositol polyphosphate 5 phosphatase OCRL1 antibody
    • Inositol polyphosphate 5-phosphatase OCRL-1 antibody
    • INPP5F antibody
    • LOCR antibody
    • Lowe oculocerebrorenal syndrome protein antibody
    • NPHL2 antibody
    • OCRL 1 antibody
    • OCRL antibody
    • OCRL_HUMAN antibody
    • OCRL1 antibody
    • Oculocerebrorenal syndrome of Lowe antibody
    • Phosphatidylinositol polyphosphate 5 phosphatase antibody
    see all

Anti-INPP5F antibody (ab90620) 使用論文

ab90620 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"