Anti-Inhibin alpha 抗体 [EPY2782] (ab81322)

製品の概要

• 製品名Anti-Inhibin alpha antibody [EPY2782]
  Inhibin alpha 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPY2782] to Inhibin alpha
• 特異性Note: 20/23 kDa bands consist of the mature alpha chain. 50/53 kDa bands are the entire proprotein.
• アプリケーション適用あり: WB, Flow Cytmore details
  適用なし: IHC-P or IP
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human Inhibin alpha aa 1-100 (N terminal).
  Database link: P05111

• ポジティブ･コントロール
  • Human Adrenal gland, HeLa, Human placenta and LNCaP lysates.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

   

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度Tissue culture supernatant
• ポリ/モノモノクローナル
• クローン名EPY2782
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cancer
  • Growth factors
  • Hormones

アプリケーション

ターゲット情報

• 機能Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
• 組織特異性Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.
• 配列類似性Belongs to the TGF-beta family.
• 翻訳後修飾Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.
• 細胞内局在Secreted.

• Target information above from: UniProt accession P05111 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 3623 Human
  • Entrez Gene: 16322 Mouse
  • Entrez Gene: 24504 Rat
  • Omim: 147380 Human
  • SwissProt: P05111 Human
  • SwissProt: Q04997 Mouse
  • SwissProt: P17490 Rat
  • Unigene: 407506 Human

  • Unigene: 1100 Mouse
  • Unigene: 8831 Rat

  see all
• 別名
  • A inhibin subunit antibody
  • A inhibin subunit precursor antibody
  • AW55578 antibody

  • IHA antibody
  • inhA antibody
  • INHA_HUMAN antibody
  • Inhibin alpha chain antibody
  • Inhibin alpha chain precursor antibody
  • Inhibin alpha subunit antibody

  see all