リコンビナント
Anti-ING4 抗体 [EP3804] (ab108621)
製品の概要
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製品名Anti-ING4 antibody [EP3804]
ING4 一次抗体 製品一覧 -
製品の詳細Rabbit monoclonal [EP3804] to ING4
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由来種Rabbit
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アプリケーション適用あり: WB, IPmore details
適用なし: Flow Cyt,ICC or IHC-P -
種交差性交差種: Mouse, Rat, Human
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免疫原
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)
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ポジティブ･コントロール
- 293T, T47-D, Jurkat, C6, Raw264.7 and PC-12 cell lysates
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特記事項
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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精製度Tissue culture supernatant
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ポリ/モノモノクローナル
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クローン名EP3804
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アイソタイプIgG
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研究分野
関連製品
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Immunizing Peptide (Blocking)
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab108621 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000 - 1/10000. Detects a band of approximately 29 kDa (predicted molecular weight: 29 kDa).Can be blocked with Human ING4 peptide (ab197784). | |
| IP | 1/10 - 1/100. |
追加情報
Is unsuitable for Flow Cyt,ICC or IHC-P.
ターゲット情報
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機能Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
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配列類似性Belongs to the ING family.
Contains 1 PHD-type zinc finger. -
細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 51147 Human
- Entrez Gene: 28019 Mouse
- Entrez Gene: 297597 Rat
- Omim: 608524 Human
- SwissProt: Q9UNL4 Human
- SwissProt: Q8C0D7 Mouse
- Unigene: 524210 Human
- Unigene: 262547 Mouse
see all -
別名
- Brain my036 protein antibody
- Candidate tumor suppressor p33 ING 1 homolog antibody
- Candidate tumor suppressor p33 ING1 homolog antibody
see all
画像
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![Western blot - ING4 antibody [EP3804] (ab108621)](http://a.abcam.com/ps/datasheet/images/108/ab108621/ING4-Primary-antibodies-ab108621-1.jpg)
Western blot - ING4 antibody [EP3804] (ab108621)All lanes : Anti-ING4 antibody [EP3804] (ab108621) at 1/1000 dilution
Lane 1 : 293T cell lysate
Lane 2 : T47-D cell lysate
Lane 3 : Jurkat cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 29 kDa -
![Western blot - ING4 antibody [EP3804] (ab108621)](http://a.abcam.com/ps/datasheet/images/108/ab108621/ING4-Primary-antibodies-ab108621-2.jpg)
Western blot - ING4 antibody [EP3804] (ab108621)All lanes : Anti-ING4 antibody [EP3804] (ab108621) at 1/1000 dilution
Lane 1 : C6 cell lysate
Lane 2 : Raw264.7 cell lysate
Lane 3 : PC-12 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 29 kDa
参考文献
This product has been referenced in:
- Pardo M et al. Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells. Sci Rep 7:8157 (2017). Read more (PubMed: 28811661) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"