Anti-ING4 抗体 [EP3804] (ab108621)

製品の概要

• 製品名
  Anti-ING4 antibody [EP3804]
  ING4 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EP3804] to ING4
• アプリケーション
  適用あり: WB, IPmore details
  適用なし: Flow Cyt,ICC or IHC-P
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

• ポジティブ･コントロール
  • 293T, T47-D, Jurkat, C6, Raw264.7 and PC-12 cell lysates
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

   

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab^® patents

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EP3804
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation
  • HAT

関連製品

• Immunizing Peptide (Blocking)
  • Human ING4 peptide (ab197784)
• Positive Controls
  • PC12 nuclear extract lysate (ab14884)
  • T47D nuclear extract lysate (ab14896)

アプリケーション

ターゲット情報

• 機能
  Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
• 配列類似性
  Belongs to the ING family.
  Contains 1 PHD-type zinc finger.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession Q9UNL4 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 51147 Human
  • Entrez Gene: 28019 Mouse
  • Entrez Gene: 297597 Rat
  • Omim: 608524 Human
  • SwissProt: Q9UNL4 Human
  • SwissProt: Q8C0D7 Mouse
  • Unigene: 524210 Human
  • Unigene: 262547 Mouse

  • Unigene: 347910 Mouse
  • Unigene: 48967 Rat

  see all
• 別名
  • Brain my036 protein antibody
  • Candidate tumor suppressor p33 ING 1 homolog antibody
  • Candidate tumor suppressor p33 ING1 homolog antibody

  • D6Wsu147e antibody
  • D6Xrf92 antibody
  • ING 1 like protein antibody
  • ING 4 antibody
  • ING1 like protein antibody
  • ING4 antibody
  • ING4_HUMAN antibody
  • Inhibitor of growth family member 4 antibody
  • Inhibitor of growth family member 4 long isoform antibody
  • Inhibitor of growth protein 4 antibody
  • MGC12557 antibody
  • my036 antibody
  • p29 ING 4 antibody
  • p29 ING4 antibody
  • p29ING4 antibody

  see all

プロトコール

• Western blot protocols
• Immunoprecipitation protocols