Anti-ING1 抗体 [EPR6788] (ab124893)
製品の概要
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製品名Anti-ING1 antibody [EPR6788]
ING1 一次抗体 製品一覧 -
製品の詳細Rabbit monoclonal [EPR6788] to ING1
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由来種Rabbit
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アプリケーション適用あり: IHC-Fr, WB, Flow Cytmore details
適用なし: ICC/IF,IHC-P or IP -
種交差性交差種: Mouse, Rat, Human
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免疫原
Synthetic peptide corresponding to residues in Human ING1. (Uniprot: Q9UK53)
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ポジティブ･コントロール
- HepG2 lysate, HeLa lysate, MCF-7 lysate, Jurkat lysate, C6 lysate, RAW264.7 lysate, PC-12 lysate and NIH/3T3 lysate.
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特記事項
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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バッファーpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA -
精製度Tissue culture supernatant
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ポリ/モノモノクローナル
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クローン名EPR6788
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アイソタイプIgG
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研究分野
関連製品
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab124893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr | Use at an assay dependent concentration. PubMed: 26100219 | |
| WB | 1/1000 - 1/10000. Predicted molecular weight: 47 kDa. | |
| Flow Cyt | 1/10 - 1/100. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
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ターゲット情報
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機能Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
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組織特異性Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
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関連疾患Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
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配列類似性Belongs to the ING family.
Contains 1 PHD-type zinc finger. -
細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 3621 Human
- Entrez Gene: 26356 Mouse
- Entrez Gene: 306626 Rat
- Omim: 601566 Human
- SwissProt: Q9UK53 Human
- SwissProt: Q9QXV3 Mouse
- Unigene: 46700 Human
- Unigene: 508725 Human
see all -
別名
- 2610028J21Rik antibody
- AA407184 antibody
- AI875420 antibody
see all
画像
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![Western blot - Anti-ING1 antibody [EPR6788] (ab124893)](http://a.abcam.com/ps/datasheet/images/124/ab124893/ING1-Primary-antibodies-ab124893-1.jpg)
Western blot - Anti-ING1 antibody [EPR6788] (ab124893)All lanes : Anti-ING1 antibody [EPR6788] (ab124893) at 1/1000 dilution
Lane 1 : HepG2 lysate
Lane 2 : HeLa lysate
Lane 3 : MCF-7 lysate
Lane 4 : Jurkat lysate
Lane 5 : C6 lysate
Lane 6 : RAW 264.7 lysate
Lane 7 : PC-12 lysate
Lane 8 : NIH/3T3 lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 47 kDa -
![Flow Cytometry - Anti-ING1 antibody [EPR6788] (ab124893)](http://a.abcam.com/ps/datasheet/images/124/ab124893/ING1-Primary-antibodies-ab124893-2.jpg)
Flow Cytometry - Anti-ING1 antibody [EPR6788] (ab124893)Flow Cytometric analysis of ab124893, at 1/10 dilution, staining ING1 in permeabilised NIH/3T3cells (red). Isotype control (Green).
参考文献
This product has been referenced in:
- Kim SW et al. Latent progenitor cells as potential regulators for tympanic membrane regeneration. Sci Rep 5:11542 (2015). IHC-Fr ; Rat . Read more (PubMed: 26100219) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"