Anti-ING1 抗体 [EPR6788] (ab124893)

製品の概要

• 製品名
  Anti-ING1 antibody [EPR6788]
  ING1 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR6788] to ING1
• アプリケーション
  適用あり: WB, Flow Cytmore details
  適用なし: ICC/IF,IHC-P or IP
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide corresponding to residues in Human ING1. (Uniprot: Q9UK53)

• ポジティブ･コントロール
  • HepG2 lysate, HeLa lysate, MCF-7 lysate, Jurkat lysate, C6 lysate, RAW264.7 lysate, PC-12 lysate and NIH/3T3 lysate.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  pH: 7.40
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 0.05% BSA
• 精製度
  Tissue culture supernatant
• ポリ/モノ
  モノクローナル
• クローン名
  EPR6788
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Intracellular
  • p53 Pathway

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation
  • HAT

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • p53 pathway

関連製品

• Positive Controls
  • PC12 nuclear extract lysate (ab14884)
  • HeLa whole cell lysate (ab29545)
  • MCF7 whole cell lysate (ab3871)
  • NIH 3T3 whole cell lysate (ab7179)
  • RAW 264.7 whole cell lysate (ab7187)
  • Jurkat whole cell lysate (ab7899)
  • HepG2 whole cell lysate (ab7900)

アプリケーション

ターゲット情報

• 機能
  Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
• 組織特異性
  Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
• 関連疾患
  Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
• 配列類似性
  Belongs to the ING family.
  Contains 1 PHD-type zinc finger.
• 細胞内局在
  Nucleus.

• Target information above from: UniProt accession Q9UK53 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 3621 Human
  • Entrez Gene: 26356 Mouse
  • Entrez Gene: 306626 Rat
  • Omim: 601566 Human
  • SwissProt: Q9UK53 Human
  • SwissProt: Q9QXV3 Mouse
  • Unigene: 46700 Human
  • Unigene: 508725 Human

  • Unigene: 25709 Mouse

  see all
• 別名
  • 2610028J21Rik antibody
  • AA407184 antibody
  • AI875420 antibody

  • Growth inhibitor ING 1 antibody
  • Growth inhibitor ING1 antibody
  • Growth inhibitory protein ING 1 antibody
  • Growth inhibitory protein ING1 antibody
  • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds antibody
  • ING 1 antibody
  • Ing1 antibody
  • ING1_HUMAN antibody
  • Inhibitor of growth 1 antibody
  • Inhibitor of growth family member 1 antibody
  • Inhibitor of growth protein 1 antibody
  • mING1h antibody
  • OTTHUMP00000018703 antibody
  • OTTHUMP00000018704 antibody
  • OTTHUMP00000018705 antibody
  • OTTHUMP00000018706 antibody
  • p24ING1c antibody
  • p33 antibody
  • p33 ING1 antibody
  • p33ING1 antibody
  • p33ING1b antibody
  • p33ING1c antibody
  • p37Ing1b antibody
  • p47 antibody
  • p47ING1a antibody
  • Tumor suppressor ING 1 antibody
  • Tumor suppressor ING1 antibody

  see all

プロトコール

• Western blot protocols
• Flow cytometry protocols