製品の概要

  • 製品名
    Indomethacin
  • 製品の詳細
    Non-selective COX inhibitor
  • 生理活性の詳細
    Non-selective COX inhibitor (IC50 = 230 and 630 nM for human COX-1 and COX-2, respectively). Activates PPARα and PPARγ (EC50 = 40 nM).
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Yasuda M  et al. Dopamine D2-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating a7 nicotinic acetylcholine receptors. J Pharmacol Sci 116:274-82 (2011). Read more (PubMed: 21691039) »
  • Palomer A  et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem 45:1402-11 (2002). Read more (PubMed: 11906281) »
  • Lehmann JM  et al. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-10 (1997). Read more (PubMed: 9013583) »

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