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Anti-KAT13D / CLOCK antibody (ab5625)

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Overview

Product name

Anti-KAT13D / CLOCK antibody
KAT13D / CLOCK 抗体 (9件) 一覧

Description

Rabbit polyclonal to KAT13D / CLOCK

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse

Predicted to work with

Rat, Human

Immunogen

Synthetic peptide: SLPETAADKSQDSGSDND, corresponding to amino acids 394-411 of Mouse CLOCK, this sequence is completely conserved between mouse and human CLOCK.

SLPETAADKS QDSGSDND

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: PBS, 1mg/ml BSA

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Heart >> Cardiac metabolism
Cardiovascular >> Blood >> Blood Pressure regulation
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HAT
Epigenetics and Nuclear Signaling >> Transcription >> Transcription Factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
Neuroscience >> Neurology process >> Circadian Rhythm

Applications

Show applications key

Our Abpromise guarantee covers the use of ab5625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: 1/200Detects a band ...Read more →

    WB: 1/200Detects a band of approximately 100 kDa (predicted molecular weight: 101.5 kDa).

Target

Function

ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL.

Tissue specificity

Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

Post-translational
modifications

Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation.

Cellular localization

Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus.

Target information above from: UniProt accessionO15516 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • bHLHe8 antibody
  • Circadian locomoter output cycles kaput protein antibody
  • Circadian locomoter output cycles protein kaput antibody
  • Circadian Locomotor Output Cycles Kaput antibody
  • Circadian Locomotor Output Cycles Kaput antibody
  • Circadium Locomotor Output Cycles Kaput antibody
  • Class E basic helix-loop-helix protein 8 antibody
  • CLOCK antibody
  • Clock homolog antibody
  • Clock protein antibody
  • CLOCK_HUMAN antibody
  • hCLOCK antibody
  • KIAA0334 antibody
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Database links

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References for Anti-KAT13D / CLOCK antibody (ab5625)

ab5625 has not yet been referenced specifically in any publications.

Publishing research using ab5625? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"