Anti-Importin4 抗体 (ab99271)

製品の概要

• 製品名Anti-Importin4 antibody
  Importin4 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Importin4
• アプリケーション適用あり: IP, IHC-Pmore details
  適用なし: WB
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide corresponding to a region within amino acids 900-950 (LLPVLLSTAQ EADPEVRSNA IFGMGVLAEH GGHPAQEHFP KLLGLLFPLL A) of Human Importin4 (NP_078934.3).

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • HeLa whole cell lysate

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: 0.09% Sodium Azide
  Constituents: Tris citrate/phosphate buffer, pH 7-8
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Protein Trafficking
  • Nuclear Import / Export

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Nuclear Pore Complex

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa whole cell lysate (ab29545)

アプリケーション

ターゲット情報

• 機能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
• 配列類似性Belongs to the importin beta family.
  Contains 6 HEAT repeats.
  Contains 1 importin N-terminal domain.
• 細胞内局在Cytoplasm. Nucleus.

• Target information above from: UniProt accession Q8TEX9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 79711 Human
  • SwissProt: Q8TEX9 Human
  • Unigene: 411865 Human
• 別名
  • Imp4 antibody
  • Imp4b antibody
  • Importin 4 antibody

  • Importin 4b antibody
  • Importin-4 antibody
  • Importin-4b antibody
  • Ipo4 antibody
  • IPO4_HUMAN antibody
  • Ran binding protein 4 antibody
  • Ran-binding protein 4 antibody
  • RanBP4 antibody

  see all